By John S. Bradley, John D. Nelson et al. (eds.)
New twenty first Edition! This bestselling and ordinary source on pediatric antimicrobial therapy offers fast entry to trustworthy, up to the moment suggestions for remedy of all infectious ailments in kids.
Practical, evidence-based thoughts from the specialists in antimicrobial therapy
- Developed through unusual editorial board
- Designed when you look after childrens and are confronted with judgements each day
- New at-a-glance tables of bacterial and fungal pathogen susceptibilities to everyday antimicrobials
- New details on neonatal developmental pharmacology
- Includes therapy of parasitic infections and tropical medicine
- Updated exams concerning the energy of the advice and the extent of proof for remedy concepts for significant infections
- Anti-infective drug directory, whole with formulations and dosages
- Antibiotic remedy for overweight children
- Antimicrobial prophylaxis/prevention of symptomatic infection
- Maximal grownup dosages and better dosages of a few antimicrobials common in children
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Additional resources for 2015 Nelson's Pediatric Antimicrobial Therapy
41 See Chapter 5. – Infants (S aureus, including CA-MRSA; group A streptococcus; Kingella kingae; in unimmunized or immunocompromised children: pneumococcus, H influenzae type b) Empiric therapy: clindamycin (to cover CA-MRSA unless clindamycin resistance locally is >10%, then use vancomycin). For serious infections, ADD cefazolin to provide better MSSA coverage and add Kingella coverage. For CA-MRSA: clindamycin 30 mg/kg/day IV div q8h OR vancomycin 40 mg/kg/day IV q8h. For MSSA: oxacillin/nafcillin 150 mg/kg/day IV div q6h OR cefazolin 100 mg/kg/day IV div q8h.
May need surgical drainage for staph/strep infection; not usually needed for CSD. Following drainage of mild to moderate suppurative adenitis caused by staph or strep, additional antibiotics may not be required. For oral therapy for MSSA: cephalexin or amox/clav; for CA-MRSA: clindamycin, TMP/SMX, or linezolid. For oral therapy of group A strep: amoxicillin or penicillin V. Total IV plus PO therapy for 7–10 days. For CSD: this is the same high dose of azithromycin that is recommended routinely for strep pharyngitis.
1,27–30 Empiric therapy: ceftazidime 150 mg/kg/day IV div q8h, or cefepime 150 mg/kg/day IV div q8h or cefotaxime 200 mg/kg/day IV div q6h AND clindamycin 40 mg/kg/day IV div q8h (BIII); OR meropenem 60 mg/kg/day IV div q8h; OR pip/tazo 400 mg/kg/day pip component IV div q6h (AIII). ADD vancomycin for suspect CA-MRSA, pending culture results (AIII). Group A streptococcal: penicillin G 200,000– 250,000 U/kg/day div q6h AND clindamycin 40 mg/kg/day div q8h (AIII). Mixed aerobic/anaerobic/gram-negative: meropenem or pip/tazo AND clindamycin (AIII).