By David Woolley, Visit Amazon's Adam Woolley Page, search results, Learn about Author Central, Adam Woolley,
This useful, simple, and informative textual content surveys easy rules of toxicology. it truly is a useful advisor to comparing toxicity and similar info, drawing close toxicity trying out and interpretation, and knowing the techniques of possibility prediction and danger evaluation and management.
A advisor to functional Toxicology:
- examines the way to overview numerous teams of chemicals—pharmaceuticals, cosmetics, and agrochemicals
- provides insights on toxicity decision, normality and naturality, prediction, and regulation
Two all-new chapters cover:
- safety pharmacology
- evaluation of alternative chemical classes
Read Online or Download A Guide to Practical Toxicology: Evaluation, Prediction, and Risk, Second Edition PDF
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Extra info for A Guide to Practical Toxicology: Evaluation, Prediction, and Risk, Second Edition
A plethora of evidence indicates that animals can be good models for the behavior of chemicals in humans and that they are the 30 A Guide to Practical Toxicology 2nd Edition only ethical and valid test system. Evidence also suggests that they are not good models and that their use should be discontinued completely. Both positions are extremes and inevitably the truth probably lies between them. In other words, an ideal situation is where the use of animals is reduced to an extent where there is sufﬁcient scientiﬁc “comfort” to make a sensible and secure assessment of the risks.
The end result, however, is that toxicity is usually expressed through speciﬁc organs, known as target organs. The problem with this approach is that many of the more potent, often less biochemically speciﬁc chemicals, affect a wide range of organs or tissues. TARGET ORGAN EXPRESSION OF TOXICITY As suggested, the disadvantage of the classic approach to target organ toxicity is that, too often, the organ is considered in isolation from other organs or from the rest of the organism. It is convenient to teach toxicology in this way, but it means that it can be difﬁcult to cross-link information so that interrelationships are evident.
People harvesting parsnips or celery may show phytophotodermatitis, which results from the transfer of psoralens from the plants to the skin and exposure to sunlight, a relationship that may not be readily identiﬁed clinically. From the above, it should be evident that toxicity is manifested in many different ways and can be seen as changed organ function, reproductive effects (sterility, impotence, teratogenicity, loss of libido, transplacental cancer), changes in normal biochemistry, excess pharmacological action, phototoxicity, or as cancer.