By Shayne C. Gad
Acute toxicology checking out offers the 1st defensive position opposed to probably harmful chemical substances. This e-book is an entire and sensible advisor to carrying out and studying all regulatory required and typical acute toxicity exams. It provides designated protocols for all the universal try designs and experiences their improvement and ambitions. Acute Toxicology trying out, moment Edition will curiosity not just employees within the pharmaceutical undefined, but in addition researchers and scholars in toxicology and public health.
* Over a hundred tables summarizing and analyzing results
* whole insurance of all significant try out designs and their obstacles and advantages
* present prestige of other attempt designs and versions
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Additional info for Acute Toxicology Testing
5-g portion is weighed and placed on the gauze patch. The test substance patch is placed on the appropriate skin site and secured. 5 ml of physiological saline. 8. 5 g. , the gauze patch designated for the test sample is secured to the appropriate skin site with one of four strips of tape at the most ventral position of the animal. 5 ml is carefully poured from a glycine weighing paper onto the gauze patch, which is held in a horizontal (level) position 3 Tests for Dermal Irritation and Corrosion 9.
16. 39 with the other hand. The patch containing the test sample is then carefully placed into position onto the skin by raising the remaining three edges with tape dorsally until they are completely secured. 5 ml of physiological saline. If the test substance is a liquid, a patch is applied and secured to the appropriate skin site. 5 ml of test substance to the patch. If the test substance is a fabric, a 1 • 1-in. square sample is cut and placed on a patch. The test substance patch is placed on the appropriate skin site and secured.
Hair follicles and sweat glands may also serve as a route of systemic entry (for highly polar materials). Irritation is generally a localized reaction resulting from either a single or FIGURE 4 Stylizedtypical cross section of skin, showing the commoncomponents encountered. 34 Acute Toxicology Testing multiple exposure to a physical or chemical entity at the same site. It is characterized by the presence of erythema (redness) and edema and may or may not result in cell death. The observed signs are heat (caused by vessel dilation and the presence of large amounts of warm blood in the affected area), redness (due to capillary dilation), and pain (due to pressure on sensory nerves).