By David T. Curiel
Adenoviral Vectors for Gene remedy, moment Edition offers exact, complete assurance of the gene supply autos which are in line with the adenovirus that's rising as an enormous instrument in gene treatment. those interesting new healing brokers have nice strength for the therapy of illness, making gene remedy a fast-growing box for examine.
This booklet offers issues starting from the fundamental biology of adenoviruses, in the course of the building and purification of adenoviral vectors, state-of-the-art vectorology, and using adenoviral vectors in preclinical animal versions, with ultimate attention of the regulatory concerns surrounding human medical gene treatment trials. This vast scope of knowledge presents a superb review of the sector, permitting the reader to realize an entire realizing of the advance and use of adenoviral vectors.
- Provides entire insurance of the fundamental biology of adenoviruses, in addition to their building, propagation, and purification of adenoviral vectors
- Introduces universal thoughts for the advance of adenoviral vectors, in addition to state of the art equipment for his or her improvement
- Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
- Discusses application of adenoviral vectors in animal sickness models
- Considers Federal Drug management laws for human medical trials
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Extra info for Adenoviral Vectors for Gene Therapy, Second Edition
An arginine switch in the species B adenovirus knob determines high-affinity engagement of cellular receptor CD46. J Virol 2009;83:673–86. Wang H, Liaw YC, Stone D, Kalyuzhniy O, Amiraslanov I, Tuve S, et al. Identification of CD46 binding sites within the adenovirus serotype 35 fiber knob. J Virol 2007;81:12785–92. Wang H, Yumul R, Cao H, Ran L, Fan X, Richter M, et al. Structural and functional studies on the interaction of adenovirus fiber knobs and desmoglein 2. J Virol 2013;87:11346–62.
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135,136,182 Many β-integrins harbor an asparagine-proline-any amino acid-tyrosine (NPXY) or NPXY-like motive in their cytoplasmic domain, which binds to cargo selectors such as NUMB and Dab2. NUMB directly interacts with the adapter AP-2 and clathrin. 183 Dab2 is another adapter molecule that initiates CME by bridging β-integrins with clathrin and PI4,5P2. 184,185 This suggests a certain redundancy, perhaps ensuring efficient endocytosis under diverse conditions. Membrane shaping might require actin, depending on the cell type.