Download Apoptosis, Cell Signaling, and Human Diseases: Molecular by Rakesh Srivastava PDF

By Rakesh Srivastava

ISBN-10: 1597451991

ISBN-13: 9781597451994

Apoptosis, mobilephone Signaling, and Human illnesses: Molecular Mechanisms, Volumes 1 and a pair of, current a concise synthesis of contemporary advancements within the realizing of either mobile survival and apoptotic pathways. specific awareness is given to apoptosis in human ailments, resembling various types of melanoma. those accomplished volumes combine the main cutting edge and present findings. The individuals are on the leading edge of medical discovery.

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33. Meinkoth JL, Ji Y, Taylor SS, Feramisco JR. Dynamics of the distribution of cyclic AMPdependent protein kinase in living cells. Proc Natl Acad Sci USA 1990;87:9595–9599. 34. Vallee RB, DiBartolomeis MJ, Theurkauf WE. A protein kinase bound to the projection portion of MAP 2 (microtubule-associated protein 2). J Cell Biol 1981;90(3):568–576. 35. Imaizumi-Scherrer T, Faust DM, Barradeau S, Hellio R, Weiss MC. Type I protein kinase a is localized to interphase microtubules and strongly associated with the mitotic spindle.

We have demonstrated that this agent is able to modulate a wide set of genes related to cell proliferation and transformation (143). It was shown that in a sequence-specific manner, antisense targeted to protein kinase A RIα alters expression of the clusters of coordinately expressed genes at a specific stage of cell growth, differentiation, and activation. The genes that define the proliferation-transformation signature are downregulated, whereas those that define differentiation-reverse transformation signature are upregulated in antisense-treated cancer cells and tumors, but not in host livers.

Activation of protein kinase A (PKA by 8-ClcAMP as a novel approach for antileukaemic therapy. Br J Cancer 2004;91:186–192. 126. Tortora G, Pepe S, Yokozaki H, Clair T, Rohlff C, Cho-Chung YS. A RIa subunit antisense oligonucleotide of cAMP-dependent protein kinase inhibits proliferation of human HL-60 promyelocytic lekemia. Proc Am Acssoc Cancer Res 1990;31:38. 127. Tortora G, Clair T, Cho-Chung YS. An antisense oligodeoxynucleotide targeted against the type RII beta regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects.

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